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Moreover, Cyp2e1-/- mice showed resistance to the APAP high dose-associated hepatotoxicity, whereas human CYP2E1 transgenic mice were susceptible, suggesting that CYP2E1 is the major P450 enzyme participating in APAP activation ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

Environmental stresses can induce an increase of plant endogenous AsA (Shalata et al., 2001)

Glossary 5-mC 5-methylcytosine AD alcohol dependence AHCY SAH hydrolase AIE adolescent intermittent ethanol ALD alcohol-induced liver disease ALKBH5 AlkB homolog 5 ARC activity-regulated cytoskeleton associated protein AUD alcohol use disorder BDNF brain-derived neurotrophic factor CRE cAMP response element DA dopamine dlPFC dorsolateral prefrontal cortex DNMT DNA methyltransferase DYN dynorphin EOS endogenous opioid system eRNA enhancer RNA EZH2 enhancer of zeste homolog 2 FTO fat mass and obesity-associated protein GABA gamma-aminobutyric acid GR glucocorticoid receptor KDM lysine demethylase KMT lysine methyltransferase M6A N6-methyladenosine METTL14 methyltransferase-like 14 METTL3 methyltransferase-like 3 mPFC medial prefrontal cortex MS methionine synthase NAc nucleus accumbens NMDA N-methyl-D-aspartate NOC nociceptin NPY neuropeptide Y SAH S-adenosylhomocysteine SAM S-adenosylmethionine SARE synaptic activity response element SNP single nucleotide polymorphism WTAP Wilms tumor 1-associating protein YTHDF YT521-B homology domain family References 1

In addition, it was confirmed that this NOX2 activity mainly occurs in the membrane, not in the cytoplasm

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